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Our Goal

Improving the assessment of movement disorders

About inSignals

University of Porto spin-off company developing innovative solutions to improve therapies, promoting healthier lives and well-being among patients with movement disorders.

What we're doing

InSignals is developing iHandU, the first technological solution for quantifying muscular rigidity in patients with movement disorders.

Our goal is to ensure the development of medical devices that reduce the subjectivity of neurological assessment, supporting  clinicians and patients.

We foster a culture of equal opportunities

The Technology

There’s a lack of solutions for quantitative evaluation of patients’ muscular rigidity.

The Gap

There are millions of people worldwide suffering from neuromuscular disorders with muscle rigidity as one of the symptoms experienced.

The rigidity evaluation is important for physicians and patients as it is an indicator of disease progression and the efficacy of drugs and treatments.

Patients with Parkinson’s disease are usually evaluated according to the Unified Parkinson Rating Scale (UPDRS) where it is evaluated several patients’ physical and mental conditions. inSignals can help evaluating patient’s motor capability, including the rigidity status.

Since no device allows for quantitative measurement of rigidity, neurologists must evaluate it based on human perception. Highly experienced professionals conduct a specific manoeuvre in the patient's joint and, based on their perception, classify it on a rank scale.

Having a device to measure rigidity is especially important in Deep Brain Stimulation surgery when neurosurgeons must determine electrode placement in the patient's brain to suppress the observed motor symptoms. The electrode placement is optimized when the rigidity improvement is evaluated while in the operating room, and today, this crucial step is performed based on the specialists' perception.

Rigidity assessment is also necessary for monitoring applications. Having this device at home, provides patients and clinicians data regarding symptoms patterns and occurring events, creating reliable medical records for a better disease management.

People affected with Parkinson’s Disease
10 Million
People with Multiple Sclerosis
2.5 Million
People diagnosed with epilepsy
50 Million

iHandU can be a powerful tool to change this reality and eliminate the need for a subjective rigidity assessment.

Our Solution

iHandU aids in the management of neuromuscular disorders, starting with Parkinson’s Disease.

Small size

Small-sized wearable motion sensor and custom-made software to evaluate wrist rigidity and cogwheel effect.

Real-Time Data

Provides real-time analytical data instead of subjective evaluation of rigidity improvement.

Monitoring and DBS

Supports neurologists with accurate reports on symptoms for patient monitoring and with optimization of Deep Brain Stimulation.

Hospital Tested

Tested in Hospital de São João in Porto and proved accuracy of ~80% *

*Average accuracy when correlating iHandU assessment (objective assessment) against doctors’ assessment opinion in the theatre (subjective assessment) in our different studies.
Clinical centres supporting our studies​
+ 0
Tested with patients during DBS surgery
> 0 %
Proved accuracy

Reclaim the control
of your life

Patients must keep track of their symptoms and have access to accurate disease data. They usually have useful tools at their disposal to assist them: 

Patients with diabetes
Patients with Hypertension
Patients with movement disorders lack a device like this

For patients

We understand the importance of having a device that allows symptom tracking for better disease management. For this reason, a monitoring version of the iHandU device is being tested in a international Multi-centre Clinical Study. Patients using the monitoring version of iHandU will be able to:

For Neurologists

iHandU has versatile characteristics that can be valuable in healthcare by providing more accurate care and contributing to a cost-effective service.  Neurologists benefit from using this technology in several ways.

iHandU was designed after direct challenge proposed by a neurology team treating Parkinson’s patients.

As confirmed by neurologists, there’s a lack of quantitative evaluation solutions of patient rigidity.

In Deep Brain Stimulation surgery physicians must verify the outcome of the therapy while in the operating room and without any instrument to support rigidity assessment for the optimum electrode implantation in the brain. iHandU has a proven record in assisting the neurology team measuring patient’s rigidity while in the operating room. Preliminary data from clinical studies indicate that iHandU improves the clinical outputs of Deep Brain stimulation to provide better patients’ quality of life.

The first version of iHandU, used in DBS surgery, was highly effective in assessing the rigidity improvement associated with optimal electrode placement.

We are extending the application of iHandU to monitor patients’ symptoms. Turning iHandU into a valuable remote patient monitoring tool for neurologists to provide high-quality care for their patients and promoting a personalized medicine.

With iHandU, it will be possible for physicians to:

For researchers

Since the human brain is one of the most sophisticated systems in the world, researchers are still trying to understand how it works. Neurological diseases and movement disorders that impact the brain are both being researched, and there is still a lot to learn before humans can fully treat brain diseases.

The study of the brain, movement disorders, and physical symptoms are all intertwined. Having the assessment to one may open the door to a better understanding of the other.

At inSignals Neurotech we are concerned about contributing to the exploration of this essential subject. iHandU was also envisioned as a research instrument that could assist design a new future for the treatment and management of movement disorders.

iHandU is a valuable tool to help with gathering the scientific evidence of your project.

iHandU allows the quantitative measurement of rigidity in patients with movement disorders, as well as the assessment of other motor complaints. 

You can incorporate iHandU into your research for monitoring purposes or to explore the outcomes related to Deep Brain Stimulation surgeries.

iHandU can assist you in acquiring useful data from the assessment of physical symptoms reported by individuals with movement disorders in the monitoring context.

It can also be useful to confirm the efficacy and value of new pharmacological treatments and therapies for patients, ensuring that your solution is effective and beneficial to its users.

If you are promoting studies to monitor motor symptoms of patients with movement disorders or studies regarding Deep Brain Stimulation, this is the right tool for your research. 

We are neurotechnologists passionate to deliver better clinical outcomes

Wrist Rigidity Assessment during Deep Brain Stimulation Surgery (2015)

We designed a novel, comfortable and wireless wearable motion sensor to classify the wrist rigidity by deriving a robust signal descriptor from angular speed values and a polynomial mathematical model to classify signals using a quantitative continuous scale. The descriptor significantly (p<0.05) distinguished between non-rigid and rigid states, and the classification model labelled correctly 83.9% of the evaluated signals against the blind-agreement of two specialists. Additionally, we developed a methodology to detect cogwheel rigidity from the angular speed signal with high sensitivity (0.93). Our system provides a reliable evaluation of wrist rigidity, improving upon the inherent subjective clinical evaluation while using small, simple and easy to use motion sensors.

Presented and Published at the proceedings of the

37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

MICo – Milano Conference Center
Milan, Italy, August 25-29 2015

An Adaptive model approach for quantitative wrist rigidity evaluation during Deep Brain Stimulation Surgery (2016)

To enhance the performance of the previously presented system, we aimed to develop models for high and low baseline rigidity, according to the examiner assessment before any stimulation. This would allow a more patient-oriented approach. Additionally, usability was improved by having in situ processing in a smartphone, instead of a computer. Such a system has shown to be reliable, presenting an accuracy of 82.0% and a mean error of 3.4%. Relatively to previous results, the performance was similar, further supporting the importance of considering the cogwheel rigidity to better infer about the reduction in rigidity. Overall, we present a simple, wearable, mobile system, suitable for intra-operatory conditions during DBS, supporting a physician in decision-making when setting stimulation parameters.

Presented and Published at the proceedings of the

38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Disney’s Contemporary Resort
Orlando, Florida (USA), August 16-20 2016

iHandU: Towards the validation of a wrist rigidity estimation for intraoperative DBS electrode position optimization (2019)

Our research group has previously designed a novel, a comfortable and wireless system aiming to tackle this subjectivity. This system comprised a gyroscope sensor in a textile band, placed in the patients’ hand, which communicated its measurement to a Smartphone via Bluetooth. During the wrist rigidity evaluation exam, a signal descriptor was computed from angular velocity (w) and a polynomial mathematical model was used to classify the signals using a quantitative scale of rigidity improvement. In this presented work, we aim to develop models that consider the 3-gyroscope-axes to acquire the w and the cogwheel rigidity. Our results showed that y-gyroscope-axis remains the best way to classify the reduction, showing an accuracy of 78% and a mean error of 3.5%. According to previous results, the performance was similar and the decrease of the samples to extract the w features did not compromise system performance. The cogwheel rigidity did not improve the previous model and other gyroscope-axis beyond the y-axis decreased system performance.

Presented and Published at the proceedings of the

9th International IEEE EMBS Conference on Neural Engineering

The Hilton Union Square
San Francisco, California (USA), March 20-23 2019

iHandU: A novel quantitative wrist rigidity evaluation device for deep brain stimulation surgery (2020)

In this work, we present a system that has seen four iterations since 2015, improving accuracy, usability and reliability. We aim to review the work done so far, outlining the iHandU system evolution, as well as the main challenges, lessons learned, and future steps to improve it. We also introduce the last version (iHandU 4.0), currently used in DBS surgeries at São João Hospital in Portugal.

Published at the proceedings of

Sensors – An Open Access Journal from MDPI

January 7 2020

Partners in our mission

Institutional Shareholders

Founders of inSignals Neurotech. Joined efforts with the ambition to develop and commercialise intellectual property related with iHandU technology to relevant industrial players

INESC TEC is one of the most prestigious Portuguese research centres, specialised in computer science and systems engineering. One core area is biomedical engineering through the BRAIN research group, by inSignals Co-Founder – Prof. João Paulo Cunha

Frontier IP Group Plc unites science and commerce by identifying strong intellectual property and accelerating its development. Frontier IP is focused on building value by providing proactive and hands-on support through its team to inSignals.

Funding & Investors

InSignals has received financial support from EIT Health and from Portugal Ventures to promote relevant business activities for the project.

EIT Health is a Knowledge and Innovation Community of the European Institute of Innovation and Technology (EIT). inSignals has been receiving the support from EIT Health since 2019.

Portugal Ventures has assumed a relevant role supporting inSignals. The Portuguese venture capital is supporting the grow of the national entrepreneurship ecosystem. In 2021 Portugal Ventures believed in the work developed by inSignals and joined us.


PD Avengers is a non-profit organization for the global alliance of people with Parkinson’s, demanding change in how the disease is seen and treated. inSignals became a proud partner in 2023, joining the mission of changing today’s reality for patients managing their symptoms.

5-HT Digital Hub Chemistry & Health, as part of the Digital Hub Initiative of the German Federal Ministry of Economics and Climate Protection, supports healthcare companies in developing digital innovations. inSignals joined the Hub to stay in close touch with the Pharma industry.


Social Media

We are bringing to market a versatile tool for rigidity measurement, capable of improving the treatment and the lives of patients with neuromuscular disorders.

To demonstrate this, we are currently undergoing more clinical trials throughout Europe and US to confirm that our technology is successful.

Do you want to collaborate with us? Send us an email!

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